Thesis (Ph.D) - University of Birmingham, Department of Medicine, Faculty of Medicine and Dentistry.
|Statement||by Philip McTernan.|
Summary Neuroplasticity, Development, and Steroid Hormone Action explores the effects of steroid hormones on brain development, function, and aging and is a compilation of cutting-edge research of concern to the disciplines of neurobiology, neuroendocrinology, endocrinology, and developmental biology. The thyroid hormone 3,5,3'-L-triiodothyronine (T3) also plays a role in the control of HL60 differentiation. Ballerini et al. showed that treatment of HL60 cells with L. A. Wallington et al. T3 decreases the amount of all-irons RA required for induction of neutrophil by: 5. Book Description. Neuroplasticity, Development, and Steroid Hormone Action explores the effects of steroid hormones on brain development, function, and aging and is a compilation of cutting-edge research of concern to the disciplines of neurobiology, neuroendocrinology, endocrinology, and developmental biology. The importance of the thyroid hormone axis in the regulation of skeletal growth and maintenance has been well established from clinical studies involving patients with mutations in proteins that Cited by:
The molecular mode of action of RA may This "late" segment thus specifies differentiation lineage. The HL cell line has been used as an archetype model to study the RA-induced conversion of a differentiatively uncommitted, proliferatively active steroid thyroid hormone receptor superfamily. A precedent for suchCited by: Introduction. Thyroid hormone, T3, regulates gene expression through direct binding of its receptor, T3R, to the recognition elements, TREs, in the DNA of affected genes .T3R belongs to the nuclear receptors family, ligand dependent transcription factors that respond to extracellular signals by retinoids, steroid hormones and other lipophilic by: 7. Tetraiodothyroacetic acid (tetrac) blocks angiogenic and tumor cell proliferation actions of thyroid hormone initiated at the cell surface hormone receptor on integrin alphavbeta3. 2) Which of the following hormones acts on its target tissues by a steroid hormone mechanism of action? a. thyroid hormone b. parathyroid hormone (PTH) c. Antidiuretic hormone (ADH) on the collecting duct d. B1 adrenergic agonists e. Glucagon.
Mechanism of Hormone Action. Before we understand the mechanism of hormone action, let’s look at what are hormone receptors. Each hormone has receptors that are found on the cell membrane of the target organ. Once the hormone bind to its designated receptor, a series of actions are initiated to release secondary messengers inside the cell. The steroid hormones are all derived from cholesterol. Moreover, with the exception of vitamin D, they all contain the same cyclopentanophenanthrene ring and atomic numbering system as conversion of C 27 cholesterol to the , , and carbon steroid hormones (designated by the nomenclature C with a subscript number indicating the number of carbon . I. INTRODUCTION. Thyroid hormones (THs) play critical roles in differentiation, growth, and metabolism. Indeed, TH is required for the normal function of nearly all tissues, with major effects on oxygen consumption and metabolic rate ().Disorders of the thyroid gland are among the most common endocrine maladies. The demonstration of thyroid hormone receptor expression in Sertoli cells (20, 21) further verifies that thyroid hormone acts directly on Sertoli cells. Although thyroid hormone is the best described modulator of Sertoli cell differentiation, two other factors have a suggested role: retinoic acid (RA) and testosterone (T).Cited by: